Robert Damoiseaux, Director
High-throughput screening (HTS) involves assaying a large number of samples in order to identify those that have a specific biological or chemical function. In classic drug discovery and chemical genomics these samples are unique small organic molecules. However, we use as well functional genomics approaches. The available technologies include RNAi, shRNA and cDNA-overexpression which allow for modulating genes of interest to study their function.
Pharmaceutical and biotech companies have traditionally performed the lion's share of
HTS. The Molecular Screening Shared Resource (MSSR) at CNSI will open these HTS
capabilities to a wider academic and public research community to accelerate the pace of
basic science as well as its translation into improved health. Through close
collaborations between physicians, biologists, and chemists, it is our goal to identify
molecules with novel functions in basic cellular and molecular biology, and to develop
probes and research tools whose uses include but are not limited to direct drug discovery.
The MSSR will serve the long-term goals of basic science and health research by
providing a much broader range of screens than commercial firms typically undertake.
In addition, the MSSR will incorporate new nanotechnologies into the screening process
in order to advance miniaturization, improve throughput and reduce costs.
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